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  • Title: [Free energy linearity principle in enzymatic catalysis and thermodynamic principles of specificity].
    Author: Kozlov LV.
    Journal: Biokhimiia; 1981 Aug; 46(8):1369-75. PubMed ID: 7272358.
    Abstract:
    It was demonstrated that the free energy linearity principle, i.e. relationship between the kinetics and thermodynamics of enzymatic reactions, can be applied to enzymatic hydrolysis of specific substrates of chymotrypsin, thus suggesting that the substrate binding energy can be utilized for decreasing the activation barrier of the reaction. The literary data support the applicability of the free energy linearity principle to enzymatic reactions catalyzed by some hydrolytic enzymes.
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