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  • Title: Testosterone-dependent changes in vivo and in vitro in the structure of the renal glomeruli of the teleost Gasterosteus aculeatus L.
    Author: de Ruiter AJ.
    Journal: Cell Tissue Res; 1981; 219(2):253-66. PubMed ID: 7273100.
    Abstract:
    During the reproductive period of the male stickleback, structural and functional changes of the kidney take place, both in the glomeruli and in the renal tubule cells. The structural changes in the glomeruli involve almost all glomerular components and point to a reduction of the glomerular filtration rate. The purpose of this study was to investigate whether these changes are controlled by testosterone, indirectly or directly. In vivo experiments demonstrated that exposures of immature castrates for 8 days to methyltestosterone leads to activation of mesangial cells and podocytes, to slight expansion of mesangial matrix and slight thickening of basal lamina. Observations on cultured renal tissue showed that two androgens, 11-ketotestosterone and methyltestosterone, are also able to stimulate the secretory activity of podocytes and mesangial cells in vitro. The results therefore indicate, that most glomerular changes in male sticklebacks during the reproductive season are directly effected by testosterone.
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