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  • Title: Cytotoxicity and mutagenicity of the fungicides captan and folpet in cultured mammalian cells CHO/HGPRT system).
    Author: O'Neill JP, Forbes NL, Hsie AW.
    Journal: Environ Mutagen; 1981; 3(3):233-7. PubMed ID: 7274179.
    Abstract:
    The cytotoxicity and mutagenicity of the fungicides captan and folpet were determined in the CHO/HGPRT system which utilizes Chinese hamster ovary cells and resistance to 6-thioguanine to estimate mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus. Treatment of cultures with each compound for 5 hr is serum-free medium resulted in reproducible, significant, concentration-dependent increase in the frequency of 6-thioguanine-resistant mutants.
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