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  • Title: [Effect of hydrocortisone and cholinolytics on the resistance of rat erythrocytes to hypoosmotic hemolysis].
    Author: Nezhentsev MV.
    Journal: Farmakol Toksikol; 1981; 44(2):188-91. PubMed ID: 7274426.
    Abstract:
    It was shown in experiments in vitro that hydrocortisone, gangleron and benzohexonium at a concentration of 10(-6) M increase the resistance of rat red cells to hypoosmotic hemolysis. Diplacin, d-tubocurarin, methamysil and methacin at the same concentration produce no effect on the resistance. Repeated injections of hydrocortisone to rats decrease the osmotic resistance of red cells, while diplacin and d-tubocurarin increase it. Combined use of hydrocortisone and cholinolytics made it possible to reveal the ability of diplacin and d-tubocurarin to reduce the effect of the steroid on the osmotic resistance of red cells both in vitro and in vivo.
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