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  • Title: Sister-chromatid exchanges are not directly related to 6-thioguanine-resistant mutations induced by ultraviolet radiation in V79 Chinese hamster cells.
    Author: Fujiwara Y, Tatsumi M, Kano Y, Yamamoto K, Miyazaki N, Paul P, Goto K, Ichihashi M.
    Journal: Gan; 1981 Feb; 72(1):145-50. PubMed ID: 7274639.
    Abstract:
    A comparison of the effects of caffeine on ultraviolet (UV)-induced sister-chromatid exchanges (SCEs) and 6-thioguanine-resistant (6-TGr) mutations was attempted in order to study how the SCE mechanism correlates with mutagenesis. The linear UV dose-mutation relation indicated that the presence of 1mM caffeine during the 6-day expression period prior to the 6-TG selection did not alter the 6-TGr mutation induction rate. However, 1mM caffeine synergistically elevated the rate of UV-induced, immediate SCE formation, but did not alter the delayed SCE frequency in the 6-day survivors. These results indicate a clear dissociation of SCE from mutation, and suggest that SCE formation may not primarily involve the mutagenic process, but may rather be an error-proof mechanism that can tolerate some of DNA lesions.
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