These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Liquid chromatographic method for determination of arprinocid in feed: collaborative study.
    Author: Fink DW.
    Journal: J Assoc Off Anal Chem; 1981 Jul; 64(4):973-9. PubMed ID: 7275914.
    Abstract:
    An HPLC method for determining arprinocid [9-(2-chloro-6-fluorophenyl)methyl-9H-purin-6-amine] in feed was evaluated in an interlaboratory collaborative study. The samples were prepared in pairs from feeds obtained from 2 commercial feed manufacturers to cover the concentration range 0.0050-0.0070% arprinocid and were distributed to 14 laboratories. Each collaborator was requested to perform one determination on each of 6 samples. In this analytical procedure, the drug is extracted into CHCl3 and, after appropriate sample preparation by liquid-liquid partitioning, determined using a silica column and ultraviolet detection. The means of the analyses reported by the collaborators ranged from 97 to 104% of the true concentration of arprinocid and were not significantly different (P greater than 0.1) from the true values. The average coefficient of variation was 6.8%. The precision standard deviations of the 3 unit blocks (sr) were each less than 0.0004% arprinocid, and the F-test demonstrated that systematic error (sb) did not make a statistically significant contribution (P greater than 0.1) to the standard deviation of the data (sd). This method has been adopted official first action.
    [Abstract] [Full Text] [Related] [New Search]