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  • Title: Hypothalamic hypothyroidism causing spastic paraplegia: recovery following thyroid medication.
    Author: Jackson IM, Papapetrou PD, Hills JR, Kassirer M.
    Journal: Ann Neurol; 1978 May; 3(5):458-61. PubMed ID: 727728.
    Abstract:
    A 63-year-old woman with longstanding spastic paraplegia and neurological evidence of long tract disturbance was found to have hypothyroidism, partial diabetes insipidus, hyperprolactinemia, and gonadotropin deficiency of hypothalamic origin. Replacement therapy with thyroxine and prednisone induced complete remission of the neurological abnormalities. The association of spastic paraplegia with hypothalamic insufficiency has not been reported previously. The possibility of hypothalamic disease should be considered in cases of spastic paraplegia of unknown cause.
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