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  • Title: Eseroline: a new antinociceptive agent derived from physostigmine with opiate receptor agonist properties. Experimental in vivo and in vitro studies on cats and rodents.
    Author: Bartolini A, Renzi G, Galli A, Aiello PM, Bartolini R.
    Journal: Neurosci Lett; 1981 Sep 01; 25(2):179-83. PubMed ID: 7279315.
    Abstract:
    We report that eseroline, until now thought devoid of any biological action, is a potent antinociceptive agent. Its antinociceptive action is stronger than that of morphine in all tests studied and, though shorter lasting than that of the latter, has a latency of only a few minutes by subcutaneous route. Eseroline, like morphine and enkephalins, inhibits the electrically evoked twitches of the mouse vas deferens and of the guinea-pig ileum. Eseroline, moreover, releases 5-hydroxytryptamine from cat brain cortex in way similar to that of morphine and physostigmine.
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