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  • Title: The inhibitor of prothrombin conversion in plasma of patients on oral anticoagulant treatment.
    Author: Bertina RM, Westhoek-Kuipers ME, Alderkamp GH.
    Journal: Thromb Haemost; 1981 Jun 30; 45(3):237-41. PubMed ID: 7281102.
    Abstract:
    Pooled plasma of patients under stable oral anticoagulation has been analysed with respect to the presence of the vitamin-K dependent factors (factors II, VII, IX and X). Of all factors 1.5-2 times more antigen than procoagulant activity was present. The concentration of factors II, X (measured spectrophotometrically) and VI is about 0.25 U/ml while factor IX is slightly higher. Coagulation assays of factor X always gave lower values than the spectrophotometric assay. This discrepancy was not influenced by the removal of either factor II-, factor VII- or factor IX antigen. However, when the factor X antigen was replaced by normal factor X, all factor X assay gave identical results, indicating that PIVKA X is responsible for these discrepancies. Using the technic of the Thrombotest-dilution curve it was shown that PIVKA X is the factor that causes the abnormal prolongation of ox-brain prothrombin time in these plasmas.
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