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  • Title: [Lipid composition and activity of certain enzymes in membranes of intestinal epithelium microvilli in rats with experimental hypercholesterinemia].
    Author: Datsenko ZM, Volkov GL, Govseva NN, Nikiforova TN.
    Journal: Ukr Biokhim Zh (1978); 1981; 53(4):74-9. PubMed ID: 7281259.
    Abstract:
    It is established that in membranes of small intestine epithelial cells microvilli in rats, which were administered cholesterol for a long time, the content of this sterol and its esters as well as of phospholipids is different. Differences in the content of lipids are a reason of changes in the sucrose, alkaline phosphatase and leucilamino-peptidase activities. These changes are accompanied by an increase on the molar cholesterol esters-free cholesterol ratio in blood plasma and cholesterol-phospholipids ratio in the microvilli membranes. Beta-sitosterol administered to experimental animals incorporates into the intestine plasma membranes, blocks up the transfer sites, inhibiting cholesterol absorption, which evidently decreases the sterol content in blood serum.
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