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  • Title: [Effect of the long-term administration of testosterone on induction of cytochrome P-450 in female rat live tissue using phenobarbital].
    Author: Chistiakov VV, Prikhod'ko AZ.
    Journal: Vopr Med Khim; 1981; 27(3):340-2. PubMed ID: 7281573.
    Abstract:
    A preadministration of testosterone propionate into rat females within 8 days caused an increase in the inducing effect of phenobarbital (after its single injection) on the content of cytochrome P-450 in liver tissue. The administration of testosterone did not affect the content of the enzyme in liver tissue. A shown in the experiments on phenobarbital induction of the enzyme as a function of duration of testosterone administration, two maximal peaks, within 1 and 8 days, were observed after preadministration of the hormone. The hormone influenced mainly on the rate of the increase in cytochrome P-450 content but not on degree of its induction.
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