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  • Title: [Alkylation of liver DNA purines in rats of different age treated with diethylnitrosamine].
    Author: Likhachev AIa, Anisimov VN, Ovsiannikov AI.
    Journal: Vopr Med Khim; 1981; 27(3):349-52. PubMed ID: 7281575.
    Abstract:
    24 hrs after oral administration of 14C-diethylnitrosamine (DENA) at a dose of 280 mg/kg into male rats the level of 7-ethyl guanine was similar in both young and old (3 and 14 months, respectively) animals whereas the level of O6-ethylguanine was increased 2-fold higher in old animals. The rate of 7-ethylguanine and O6 ethylguanine elimination from liver DNA was higher in the young rats. The rate of incorporation of 3H-thymidine into liver DNA was decreased in the old animals. Administration of DENA (280 mg per kg) 50 hrs before the injection of the labelled thymidine inhibited its incorporation into the liver DNA in the young rats and did not alter the process in the old rats. The data obtained suggest an important role of age-dependent decrease in proliferative processes in liver tissue of the old rats in the response to carcinogenic effect of DENA.
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