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  • Title: [Comparison of the effects of natural and synthetic secretin on the exocrine secretion of the human pancreas (author's transl)].
    Author: Hoppe B, Fritsch WP, Scholten T, Rick W, Strohmeyer G.
    Journal: Z Gastroenterol; 1980 Dec; 18(12):625-32. PubMed ID: 7281853.
    Abstract:
    In 16 healthy male subjects the effects of natural and synthetic secretin on the function of the exocrine pancreas were compared. Following; stimulation with secretin in all cases pancreozymin was injected to ascertain normal pancreatic secretory capacity. The methods applied corresponded to those used in the multicenter study of the European Pancreatic Club. No significant differences were found between the results concerning volume of secretion, maximal bicarbonate concentration, maximal bicarbonate output and enzyme secretion rates after stimulation with natural and synthetic secretin, respectively. It is concluded that the synthetic peptide can be utilized in the same way as the natural product in the secretin-pancreozymin-test.
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