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  • Title: Kainic acid induced lesion of ventral tegmental area: locomotor effect of apomorphine.
    Author: Morgenstern R.
    Journal: Acta Biol Med Ger; 1980; 39(8-9):911-5. PubMed ID: 7282221.
    Abstract:
    Kainic acid induced lesion of dopaminergic ventral tegmental area (KA-A10) result in a permanent behavioral syndrome in the rat in which locomotor hyperactivity is the most typical symptom. Apomorphine in low doses (0.125 and 0.25 mg/kg i.p.) was as active as haloperidol (0.25 mg/kg i.p.) in abolishing this locomotor hyperactivity while higher doses of apomorphine were less active. The KA-A10 lesion is discussed as a model of mesolimbic/mesocortical dopaminergic hyperactivity.
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