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  • Title: Interlaboratory survey of Enzyme Analyses iii. Does College of American Pathologists' survey serum mimic clinical specimens?
    Author: Lott JA, O'Donnell NJ, Grannis GF.
    Journal: Am J Clin Pathol; 1981 Oct; 76(4 Suppl):554-66. PubMed ID: 7282641.
    Abstract:
    Participants in the last College of American Pathologists Enzyme Surveys in 1978 were asked that they provide results for lactate dehydrogenase (LD), alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and creatine kinase (CK), for the six interrelated Enzyme Survey serum specimens, and were also asked to provide results for the same enzymes from six healthy persons and from 50 patients. Extensive data analysis revealed that porcine LD and CK in the Survey serum had kinetic properties similar to the native enzymes in fresh human serum. On this basis, we were able to merge the normal data from laboratories using diverse methods and to establish a "universal" reference range for these two enzymes. Survey serum may serve as a bridge for the clinical comparison of very diverse methods for determining LD and CK, possibly for AST and ALT, but not for ALP.
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