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  • Title: Experimental endocarditis caused by Streptococcus sanguis: single and combined antibiotic therapy.
    Author: Vicente MV, Olay T, Rodríguez A.
    Journal: Antimicrob Agents Chemother; 1981 Jul; 20(1):10-4. PubMed ID: 7283409.
    Abstract:
    The effectiveness of penicillin G, fosfomycin, and cefoxitin alone and in combination was studied in vitro and in the treatment of left-sided Streptococcus sanguis endocarditis in rabbits. In vitro, the combinations penicillin G plus fosfomycin, penicillin G plus cefoxitin, and fosfomycin plus cefoxitin were synergistic or partially synergistic for S sanguis. Therapy with the combinations was more effective in eradicating the species from cardiac vegetations that was that with each antibiotic used alone.
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