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  • Title: [Quantitative electron microscopic and cytological analysis of breast cancer of various degrees of anaplasia].
    Author: Iagubov AS, Agamov KA, Sidorova NA.
    Journal: Arkh Patol; 1981; 43(5):41-7. PubMed ID: 7283786.
    Abstract:
    Electron microscopic and cytological study of mammary carcinoma cells of different degrees of anaplasia was carried out using morphometric methods in 15 patients with infiltrating carcinoma of this localization and correlation of cytological and histological data. The results showed the quantitative ultrastructural characteristics of the infiltrating mammary carcinoma reflecting the level of development of granular reticulum and polyribosomal apparatus to differ significantly depending on the degree of the tumor anaplasia established by cytological and histological studies with a light microscope. The cytological signs showing the maximum correlation with the ultrastructural changes in cells were found to include the numbers of "naked" nuclei, sizes of the cells and nuclei, number of nucleoli in the cell. Combinations of these signs typical for mammary carcinoma of different degrees of anaplasia are described.
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