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  • Title: [3H]Dopamine accumulation and release from striatal slices in young, mature and senescent rats.
    Author: Thompson JM, Whitaker JR, Joseph JA.
    Journal: Brain Res; 1981 Nov 16; 224(2):436-40. PubMed ID: 7284852.
    Abstract:
    Examinations of [3H]dopamine ([3H]DA) release following KCl or amphetamine administration in striatal slices from young (7 month), and senescent (24 month) Wistar rats showed no age-related changes. Further, the amount of [3H]DA accumulated in the striatal slices showed no changes with age. Thus, previously reported age-related deficits in motor behavior (i.e. rotational) are not produced by changes in striatal DA accumulation or release.
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