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  • Title: Body fluid lithium measurements: severity of illness and prediction of outcome.
    Author: Davis RA, Taylor MA, Abrams R.
    Journal: Biol Psychiatry; 1978 Oct; 13(5):595-9. PubMed ID: 728511.
    Abstract:
    The authors measured lithium ion in saliva and serum 24 hr after a loading dose of lithium, and recorded the amount of lithium excreted in the urine during the 24-hr test period. Their results support previous work indicating a correlation between serum and mixed saliva lithium levels. On a subsample of manic patients, no correlation could be found between lithium retention and clinical outcome, age of onset, or pretreatment severity of illness. In addition, they were unable to confirm a prior report that the 24-hr postloading dose serum lithium level was a predictor of eventual therapeutic dosage.
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