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  • Title: Sodium inactivation mechanism modulates QX-314 block of sodium channels in squid axons.
    Author: Yeh JZ.
    Journal: Biophys J; 1978 Nov; 24(2):569-74. PubMed ID: 728531.
    Abstract:
    Blocking action of Na channels by QX-314, a quaternary derivative of lidocaine, was studied in internally perfused and voltage-clamped axons of squid. In axons with intact Na inactivation, QX-314 exhibited both a frequency- and a voltage-dependent block of Na channels. Repetitive pulsing to more positive potentials enhanced the degree of block. Both frequency- and voltage-dependent blocks disappeared in axons in which Na inactivation had been destroyed by either pronase or N-bromoacetamide treatment. These results support the notion that Na inactivation not only modulates the frequency-dependent block but also involves the voltage-dependent binding reaction between QX-314 and Na channels.
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