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  • Title: Altered red blood cell surface area in hereditary xerocytosis.
    Author: Sauberman N, Fairbanks G, Lutz HU, Fortier NL, Snyder LM.
    Journal: Clin Chim Acta; 1981 Aug 10; 114(2-3):149-61. PubMed ID: 7285342.
    Abstract:
    Hereditary xerocytes appear larger than normal red cells in scanning electron micrographs and exhibit a higher ghost packing volume. The major chemical components--protein, phosphorus, cholesterol and sialic acid--are increased uniformly, as are all polypeptides visible on gel electrophoresis patterns of xerocyte membranes. These data are consistent with a xerocyte surface area 15 to 25% above normal. Certain clinical anomalies common to this disorder, including unexpectedly low reticulocyte count and 2,3-diphosphoglycerate level, are discussed in the light of the present findings.
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