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  • Title: Pharmacokinetics of ethynyloestradiol in women for different populations.
    Author: Fotherby K, Akpoviroro J, Abdel-Rahman HA, Toppozada HK, de Souza JC, Coutinho EM, Koetsawang S, Nukulkarn P, Sheth UK, Mapa MK, Gopalan S, Plunkett ER, Brenner PF, Hickey MV, Grech ES, Lichtenberg R, Gual C, Molina R, Gomez-Rogers C, Kwon E, Kim SW, Chan T, Ratnam SS, Landgren BM, Shearman RP, Goldzieher JW, Dozier TS.
    Journal: Contraception; 1981 May; 23(5):487-96. PubMed ID: 7285572.
    Abstract:
    The pharmacokinetics of a dose of 50 microgram ethynyloestradiol administered orally was studied in fourteen centres. Absorption was rapid and the highest serum concentrations of total ethynyloestradiol were found in most subjects at 1 h and by 24 h concentrations were less than 250 pg/ml. Calculation of the half-lives for absorption, distribution and elimination showed wide variations between subjects, the half-life of elimination varying from 2.5 h to more than 30 h. Bioavailability as measured by the area under the serum ethynyloestradiol concentration-time curve also showed more than a ten-fold variation. Intra-centre differences in the various parameters measured were as large as the inter-centre differences.
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