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  • Title: Oxidation of meso-diaminosuccinic acid, a possible natural substrate for D-aspartate oxidase.
    Author: Rinaldi A, Pellegrini M, Crifò C, De Marco C.
    Journal: Eur J Biochem; 1981 Jul; 117(3):635-8. PubMed ID: 7285908.
    Abstract:
    meso-Diaminosuccinic acid, a natural antagonist of aspartic acid, is a good substrate for beef kidney D-aspartate oxidase. The oxygen consumption and the ammonia production are in good agreement with the stoichiometry of a typical oxidative deamination. The deamination involves only one of the two amino groups of diaminosuccinate, and is followed by decarboxylation of the first reaction product, 2-amino-3-oxosuccinic acid. By condensation of the compounds thus originating from this latter, pyrazine 2,5-dicarboxylic acid and pyrazine 2,6-dicarboxylic acid are formed. DL-Diaminosuccinic acid is not oxidized by D-aspartate oxidase, nor does it inhibit the enzyme activity.
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