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  • Title: [Toxicological and radiobiological characteristics of meprin S-derivatives].
    Author: Pantev TP, Topalova SP, Isakov IL.
    Journal: Farmakol Toksikol; 1981; 44(4):476-8. PubMed ID: 7286211.
    Abstract:
    The effect was studied of synthetic thiosulfo- (TSPG), thiophospho- (TPPG), isothiuronium- (ITPG), and diethyldithiocarbamate (DDTKPG) alpha-mercaptopropionylglycine derivatives (alpha-MPG). Their toxicological and radiobiological characteristics were disclosed on mice exposed to gamma rays within a dose range of 9 to 11 Gy. TSPG in a dose of 3500 to 4500 mg/kg provided a 60 to 70% survival at LD100/10. In a dose of 4000 mg/kg the drug favoured a 70% protection of experimental animals when administered 4 hours before exposure to LD60/30. A high degree of protection (90%) was seen after TPPG preadministration (800 mg/kg) and exposure to LD100/10. DDTKPG (1300 mg/kg) also increased the survival of irradiated animals. No protective effect was observed after ITPG administration in doses of 50, 100, 180 and 360 mg/kg. Low toxicity and good enough antiradiation effect of the three compounds tested enabled the authors to proceed to more extensive studies.
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