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  • Title: Lysosomal enzymes in sera and granulocytes of patients with chronic liver diseases.
    Author: Fehér J, Toncsev H, Fehér E, Kiss A, Vasady A.
    Journal: Int J Tissue React; 1981 Mar; 3(1):31-7. PubMed ID: 7287055.
    Abstract:
    The authors have measured the activity of acid phosphatase, beta-glucuronaidase and cathepsin-D in tthe sera of patients with different liver diseases, and the actvity of beta-glucuronidase in granulocytes and the rate of its release. Using the method for the releaseof beta-glucuronidase from the granulocytes they drew conclusions to thedegree of the membrane-damage occurring in the liver diseases. They provided that in the sera of patients with different liver diseases the increase in the activity of the acid phosphatase and the beta-glucuronidase is different. According to their in vitro studies the decrease in the beta-glucuronidase activity measured in the granulocytes, and the release of enzyme is in connection with the type of liver disease and with the different degree of lysosomal membrane alteration.
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