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  • Title: Human seminal plasma contains a protein that shares physicochemical and immunochemical properties with placental protein 5 from the human placenta.
    Author: Ranta T, Siiteri JE, Koistinen R, Salem HT, Bohn H, Koskimies AI, Seppälä M.
    Journal: J Clin Endocrinol Metab; 1981 Nov; 53(5):1087-9. PubMed ID: 7287877.
    Abstract:
    Placental protein 5 (PP5)-like immunoreactive material was detected in human seminal plasma at high concentrations (32-1000 ng/ml). This was not due to interference with proteases or binding to seminal plasma proteins, since immunoreactivity was not affected by treatment with protease inhibitors, and incubation with seminal plasma of [125I]PP5 did not bring about any significant change in the elution pattern in gel filtration. Part of the PP5 immunoreactivity in seminal plasma had a molecular weight of 36,000-42,500 which is the molecular weight of purified PP5 from the human placenta. In RIa, serial dilutions of the 36,000-42,500 molecular weight material gave an inhibition curve parallel to that of the PP5 standard. The source of seminal plasma PP5-like material is not from the testes, as the levels in vasectomized men were similar to those in nonvasectomized men.
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