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  • Title: Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs.
    Author: Wasada T, McCorkle K, Harris V, Kawai K, Howard B, Unger RH.
    Journal: J Clin Invest; 1981 Oct; 68(4):1106-7. PubMed ID: 7287903.
    Abstract:
    To determine whether gastric inhibitory polypeptide (GIP) promotes the clearance of chylomicron triglycerides (TG) from the circulation in dogs, chyle collected from donor dogs via a thoracic duct fistula was infused at a rate of 2 ml/min i.v. into normal recipient dogs during an infusion of either porcine GIP (1 microgram/kg per h) or saline as a control. In the GIP-infused dogs the rise in plasma TG was significantly below that of the control animals [mean peak of 36 +/- 4 mg/dl vs. 82 +/- 18 mg/dl (P less than 0.05)]. It is concluded that GIP exerts an effect upon the removal of chylomicron TG from the blood. The results suggest that GIP may play a physiologic role in the disposition of ingested fat.
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