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  • Title: Acathisia-syndrome: involvement of noradrenergic mechanisms.
    Author: Bartels M, Gaertner HJ, Golfinopoulos G.
    Journal: J Neural Transm; 1981; 52(1-2):33-9. PubMed ID: 7288436.
    Abstract:
    The involvement of noradrenergic mechanisms in patients suffering from acathisia was investigated by determination of urinary night-time 3-methoxy-4-hydroxy-phenyl glycol (MHPG)-excretion and was compared both with control patients matched according to age and sex and healthy individuals. A significantly reduced MHPG excretion was found among the acathisia patients. It is suggested that a supersensitivity of the spinal noradrenergically innervated receptors caused by their long-term blocking is responsible for occurrence of the symptoms.
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