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  • Title: Uroepithelial carcinoma in association with cyclophosphamide ingestion.
    Author: Fuchs EF, Kay R, Poole R, Barry JM, Pearse HD.
    Journal: J Urol; 1981 Oct; 126(4):544-5. PubMed ID: 7288948.
    Abstract:
    The association of daily oral cyclophosphamide with the development of transitional cell carcinoma or squamous cell carcinoma of the bladder had been documented. We report the first 2 cases of transitional cell carcinoma of the renal pelvis and an additional 4 cases of transitional cell carcinoma of the bladder following cyclophosphamide ingestion. Patients who have been taking daily oral cyclophosphamide for a prolonged period should have excretory urography, cystoscopy and bladder mucosal biopsies performed as part of a cancer surveillance protocol.
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