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  • Title: [Energy-metabolism enzymes during combined exposure of the body to simulated weightlessness and gravitational overloads].
    Author: Vetrova EG, Drozdova TE, Tigranian RA, Shul'zhenko EB.
    Journal: Kosm Biol Aviakosm Med; 1981; 15(5):34-8. PubMed ID: 7289561.
    Abstract:
    Exposure to simulated weightlessness (7-day water immersion and 7-day head-down tilt) caused a decrease in the activity of malate (MDH) and isocitrate dehydrogenase (ICDH), and creatine phosphokinase dehydrogenase (ICDH), and creatine phosphokinase (CPK) at the expense of its MM isoform whereas the activity of alanine (ALT) and aspartate aminotransferase (AST) and pattern of distribution of MDH isoforms remained unchanged. Exposure to acceleration of +3 Gz before and after simulated weightlessness revealed similar changes in the activity of MDH, ICDH, ALT, AST and MDH cytoplasmic fractions. However, the higher increase in the enzyme activity after simulated weightlessness may give evidence for a greater change in cell membrane permeability during acceleration effects that followed simulated weightlessness.
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