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  • Title: [Sensitivity of Candida spp. to 5-fluorocytosine, amphotericin B and imidazoles. Antifongiogram of 120 strains isolated at the Vaudois University Hospital Center during the autumn-winter seasons of 1978 and 1980].
    Author: Sakellarides E.
    Journal: Schweiz Med Wochenschr; 1981 Sep 12; 111(37):1367-72. PubMed ID: 7291960.
    Abstract:
    120 strains of Candida spp were tested against the antifungal agents 5-fluorocytosine, amphotericine B and the imidazoles econazole, miconazole and clotrimazole. The proportion of resistance varied with the species and substances: Candida albicans (100 strains): 4% resistance against 5-fluorocytosine, 1% against amphotericine B, no resistance to imidazoles; Candida tropicalis and C. pseudotropicalis (15 strains): 26.7% resistance to 5-fluorocytosine, 7.1% against amphotericine B, no resistance to imidazoles; Candida krusei (5 strains): no resistance to the antifungal agents. The correlation between the diameter measurements carried out at 2 dose levels of 5-fluorocytosine (1 and 100 micrograms) and of econazole (20 and 30 micrograms) was studied statistically and the validity of the experimental data established.
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