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  • Title: Elevation of blood keto acids in cerebrocortical necrosis.
    Author: Edwin EE, Jackman R.
    Journal: Vet Rec; 1981 Jul 25; 109(4):75-6. PubMed ID: 7292935.
    Abstract:
    Values of various alpha-keto acids in whole blood were determined from cases of cerebrocortical necrosis (CCN), a thiamine deficiency disease, and were compared with those from normal animals. Thiamine pyrophosphate is an essential cofactor in the decarboxylation of many alpha-keto acids and this was reflected in elevated values not only of pyruvic acid but of glyoxylic, alpha-keto glutaric, phenyl pyruvic and hydroxyphenyl pyruvic acids in the CCN cases.
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