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  • Title: [Special action of leponex on mitochondria in cultures of human nerve tissue].
    Author: Buravlev VM.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1981; 81(7):1059-63. PubMed ID: 7293601.
    Abstract:
    The action of leponex (clozapine) on cultures of human embryonal nervous tissue was studied by the methods of optic and electron microscopy. The blood serum of schizophereniacs who received leponex in a daily dose of 200 to 500 mg was added to the culture medium. It was found that leponex (or its metabolites) increased the number of cells containing giant "monolithic" forms of mitochondria. This differentiates leponex substantially from phenothiazine, diazepine and lithium drugs, and its effects from those produced by the serum of patients suffering from other diseases (control). The ultrastructure of the monolithic mitochondria was fully preserved, and did not differ from that of the discrete forms of those organelles typical for the nervous tissue. It is supposed that the described proliferative reactions of the mitochondria may reflect a rise of the bioenergy potential of the nervous tissue under the action of leponex.
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