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  • Title: Origin of the triosephosphate isomerase isozymes in humans: genetic evidence for the expression of a single structural locus.
    Author: Decker RS, Mohrenweiser HW.
    Journal: Am J Hum Genet; 1981 Sep; 33(5):683-91. PubMed ID: 7294020.
    Abstract:
    A genetic approach is used to ascertain that a single structural locus for triosephosphate isomerase (TPI) (E.C.5.3.1.1.) is expressed in rapidly dividing human lymphoblasts. This approach is made possible through the identification of a rare electrophoretic variant of human TPI. The variant phenotype is expressed by the TPI-B isozyme in both erythrocytes and peripheral lymphocytes. The variant phenotype is also expressed in the thermostability and electrophoretic pattern of the TPI-A isozyme in mitogen-stimulated lymphoblasts, indicating that TPI-A and TPI-B are products of the same structural locus. These findings are in contrast to the recent conclusions of Yuan et al. based upon structural analysis, suggesting that the TPI-A and TPI-B isozymes are products of distinct structural loci.
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