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  • Title: [Optimization of the nutrient medium composition for the biosynthesis of the antibiotic tobramycin using a mathematical experimental design method].
    Author: Motkova MO, Korobkova TP, Gladkikh EG.
    Journal: Antibiotiki; 1981 Sep; 26(9):651-4. PubMed ID: 7294757.
    Abstract:
    The mathematical design of the experiment was used for optimization of the nutrient medium for biosynthesis of tobramycin by Streptomyces cremeus var. tobramycini. The use of the orthogonal Latin rectangles provided development of the fermentation medium composition and definition of the optimal concentration of its ingredients. The level of tobramycin production on this medium was 2 times higher than that on the initial one.
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