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  • Title: Effect of hydrogen sulfide on bacterial inactivation in the rat lung.
    Author: Rogers RE, Ferin J.
    Journal: Arch Environ Health; 1981; 36(5):261-4. PubMed ID: 7294891.
    Abstract:
    This study evaluated the effect of a low concentration of hydrogen sulfide on the rat antibacterial defense system. Rats exposed to 45 ppm hydrogen sulfide (threshold limit value for hydrogen sulfide = 10 ppm) for 4 or 6 hr exhibited a significant (P less .01) reduction in the inactivation of viable staphylococci deposited in the lungs during a bacterial aerosol challenge. Pre-exposure of rats to 46 ppm hydrogen sulfide for 2 hr, however, did not alter intrapulmonary staphylococcal inactivation. We hypothesize that impairment of the alveolar macrophage is the basis of these findings.
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