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  • Title: Immunosuppressive effect of concanavalin A. IV. The effect of Con A on the local graft versus host (GvH) reaction in the mouse popliteal lymph node.
    Author: Mioduszewska O, Mościcka-Wesołowska M, Skopińska-Rózewska E, Wasik M.
    Journal: Arch Immunol Ther Exp (Warsz); 1981; 29(3):385-90. PubMed ID: 7294974.
    Abstract:
    In the applied parental F1 hybrid system, the GvH character of the regional lymph node reaction was checked against syngeneic and the absolute control systems. It was found that a cortical B-cell zone of the recipients did not participate in the acute phase of the GvH reaction. Cytologically, the GvH response consisted in a significant increase in large pyroninophilic cells, histologically - in a cellular proliferation and pyroninophilia, as well as in a marked angiogenesis beyond the cortical zone of the lymph node. The injection of Con A into the F1 hybrid mice, 24 hours before the administration of the parental cells, inhibited the earlier (presumably donor origin) cellular reaction and intensified the later (presumably host origin) response.
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