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  • Title: [Experimental electrocardiography research. A study in the rat of the cardiovascular effects of verapamil].
    Author: Valora N, Bruno C, Floridi S, Mei V, Pranzetti P, Cherchi GM.
    Journal: Boll Soc Ital Biol Sper; 1981 Jun 30; 57(12):1352-8. PubMed ID: 7295406.
    Abstract:
    Electrocardiographic changes induced by Verapamil, drug inducing inhibition of transmembrane movement of calcium into cardiac cells and mobilization of intracellular Ca++, have been studied in 10 anesthetized rats. Authors observed that Verapamil has: 1) negative chronotropic action on SA node; sometimes appears a superior nodal rhythm; 2) inconstantly, negative dromotropic action with prolonged atrioventricular conduction and "period of Luciani-Wenckebach'; 3) effective antiarrhythmic action; 4) no protective action towards peripheric vascular epinephrine effects; 5) remarkable negative inotropic action, whose Authors consider indirect signs the electrocardiographic changes, which indicate severe coronary failure, and the death of 6 rats by acute pulmonary edema.
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