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  • Title: The effect of dietary fructose and diabetes on the rat kidney.
    Author: Boot-Handford RP, Heath H.
    Journal: Br J Exp Pathol; 1981 Aug; 62(4):398-406. PubMed ID: 7295533.
    Abstract:
    To determine whether the fructose moiety of sucrose or the lack of some factor essential for the integrity of the microvascular system is responsible for the development of sucrose-induced glomerulosclerosis, a series of diets with or without such a factor and/or fructose was fed to rats over a 6-month period. Consumption of diets containing or yielding fructose caused a significant increase in kidney weight in comparison with glucose-yielding diets. Diabetic animals also exhibited an increased kidney weight. The incidence of diffuse glomerulosclerosis, tubular damage and lymphocyte infiltration was increased in the starch-diabetic, fructose- and sucrose-normal groups. Diabetic MRC 41B- and normal MRC 41B/fructose-, MRC 41B-, glucose- and starch-fed rats (with the exception of one animal in the latter group) did not develop these kidney lesions. Sucrose-, in comparison with starch-ingestion was found to produce significant increases in blood fructose and kidney fructose-1-phosphate concentration. The results are discussed in relation to blood-glucose concentration, renal-fructose metabolism and the development of glomerular and tubular damage.
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