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  • Title: [Effect of cooling on rhythmo-inotropic relations in pathologically altered myocardium].
    Author: Vornovitskiĭ EG, Ignat'eva VB, Kaĭdash AN, Arapov AD, Mogilevskiĭ EB.
    Journal: Biull Eksp Biol Med; 1981 Jul; 92(7):10-4. PubMed ID: 7295934.
    Abstract:
    Fragments of the right atrium auricle from patients with congenital and acquired heart diseases were used to study the effect of the Tyrode solution temperature over the 60-minute cessation of electrical stimulation of the preparations on the recovery of the amplitude of rhythmic contractions after the pause. The lack of stimulation within 34 to 24 degrees C does not lower the contraction amplitude after warming of the preparations and renewal of rhythmic stimulation. The hypothermal pause at a temperature of 10-14 degrees C leads to the development of contractures and suppresses the myocardial contractility. The positive inotropic action of dopamin (1.10(-6) g/ml), isadrin (1.10(-7) g/ml) and strophanthine (1.10(-6) g/ml) on the myocardium in patients with acquired heart diseases is remarkably diminished after the hypothermal pause.
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