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  • Title: [Repair of DNA-protein cross-links induced by antineoplastic alkylating agents].
    Author: Lomova TIu, Shakhova IK, Shkodinskaia EN.
    Journal: Biull Eksp Biol Med; 1981 Jul; 92(7):74-6. PubMed ID: 7295949.
    Abstract:
    The bifunctional and antitumor alkylating agents embichin and its aromatic derivatives sarcolysin and chlorfenacyl remarkably differ in DNA-protein cross-links induction in Chinese hamster cell cultures in vitro. The differences involve the concentration necessary for cross-linkage, the time of cross-links emergence, and their reparation. Since all three compounds have the same alkylating group, it is obvious that the differences seen in the cross-linkage arise from the structure of aromatic groupings introduced into the molecule.
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