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  • Title: [Effect of splenin and its fractions on the functional state of the adrenal cortex].
    Author: Gasanov SG, Buianovskaia OA, Nechaeva EB, Trubnikov VI.
    Journal: Biull Eksp Biol Med; 1981 Jul; 92(7):98-100. PubMed ID: 7295953.
    Abstract:
    Effect of splenin (1 ml) and its fractions (0.5 ml) on adrenocortical function was studied after a single intramuscular injection of the preparations into rats. Splenin and its fractions containing water-soluble substances reduced the content of ascorbic acid in the rat adrenals thereby indicating the increased synthesis of adrenocortical hormones. Adenosine-5-monophosphate is one of the basic biological substances contained by splenin and its water-soluble fractions. It produces a stimulant effect on the synthesis of adrenocortical hormones.
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