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  • Title: [Development of liver cirrhosis in rats following stimulation of hepatic macrophages].
    Author: Kutina SN, Maianskiĭ DN.
    Journal: Biull Eksp Biol Med; 1981 Sep; 92(9):366-9. PubMed ID: 7295995.
    Abstract:
    Liver cirrhosis was induced in male Wistar rats weighing 200-250 g by subcutaneous injection of 0.25 ml of a 10% CCl4 solution per 100 g bw. Kupffer cells were stimulated with prodigiozan which was introduced at a 10-day interval in the course of fibrosis development. Under stimulation the injury to the parenchyma decreased; the total number of Kupffer macrophages and the degree of mononuclear infiltration of liver tissue increased, while fibroplasia diminished. The content of hydroxyproline in liver homogenates of prodigiozan-stimulated rats was half as much as compared with controls.
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