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  • Title: Methylxanthines antagonize adenosine but not morphine inhibition in guinea pig ileum.
    Author: Gallant CA, Clement JG.
    Journal: Can J Physiol Pharmacol; 1981 Aug; 59(8):886-9. PubMed ID: 7296387.
    Abstract:
    In the electrically stimulated guinea pig ileum longitudinal muscle strip preparation the inhibitory actions of adenosine were antagonized by various concentrations of theophylline (12.5 and 100 micro M) and 8-phenyltheophylline (4 and 20 micro M). However, the inhibitory actions of morphine were not antagonized by the same concentration of theophylline and 8-phenyltheophylline. These results suggest that in the guinea pig ileum longitudinal muscle-strip adenosine is not a mediator in the inhibitory actions of morphine.
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