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  • Title: [Praziquantel in the treatment of Far Eastern hepatic distomiasis caused by Clonorchis sinensis or Opisthorchis viverrini].
    Author: Ambroise-Thomas P, Goullier A, Wegner DG.
    Journal: Bull Soc Pathol Exot Filiales; 1981; 74(4):426-33. PubMed ID: 7296740.
    Abstract:
    Forty-six patients infected with Opistorchis viverrini and/or Clonorchis sinensis, 24 males and 22 females, all Laotian or Vietnamese, aged 7 to 68, weighing 18 to 70 kg, were detected by parasitological stool examinations, numeration of Eggs Per Gram of feces (E.P.G.). In this manner we observed 23 light infestations (1-999 E.P.G.), 20 moderate infestations (10,000-29,999 E.P.G.). Before treatment, all these patients were submitted to a complete history and clinical examination with biological controls that totaled up 47 parameters. These controls were repeated daily from the eve of the treatment to 5 days after. The treatment was given orally at the dose of 75 mg/kg of body weight in three doses 4 to 6 hours apart during the same day. The tolerance was excellent in the children who did not have any trouble even minor. The adults had only slight side-effects such as fatigue (18 cases), dizziness (19 cases) and headaches (16 cases). Light or moderate, these troubles spontaneously disappeared after one or at the most two days. Biological controls did not show any significant variation. The therapeutic efficiency appears excellent with 100% cure in 46 patients treated who were controlled daily during the first week, at the 20th and 40th day and for some of them up to seven month after treatment. These results are all the more remarkable since certain patients were severely infected and that of all the far-eastern liver flukes O. viverrini is probable the most resistant to known drugs. Very efficient and very well tolerated, praziquantel offers the advantage of one day treatment in the cure of opistorchiasis and hospitalization is not necessary.
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