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  • Title: Effect of prolactin and bromocriptine on intestinal transit in mice.
    Author: Gopalakrishnan V, Ramaswamy S, Pillai NP, Ghosh MN.
    Journal: Eur J Pharmacol; 1981 Sep 24; 74(4):369-72. PubMed ID: 7297603.
    Abstract:
    In vivo administration of relatively high concentrations of prolactin (PRL) enhanced gastrointestinal propulsion in mice. Pretreatment with atropine significantly abolished this effect of PRL while physostigmine enhanced it. The evidence confirms a cholinomimetic action for higher concentrations (20 microgram) of PRL on the intestinal tract. Bromocriptine per se produced a dose-dependent depression in transit while a combination of PRL and bromocriptine failed to significantly alter the transit as compared to the control.
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