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  • Title: Muscle beta-actinin is not chicken serum albumin.
    Author: Maruyama K, Kimura S.
    Journal: J Biochem; 1981 Aug; 90(2):563-6. PubMed ID: 7298603.
    Abstract:
    Recently, Heizmann et al. (Proc. Natl. Acad. Sci. U.S. 78, 74-77 (1981)) reported that muscle beta-actinin and serum albumin of the chicken are indistinguishable by physicochemical and immunological criteria. It should, however, be stated that the protein the above authors called beta-actinin was entirely different from genuine muscle beta-actinin (Maruyama et. al. (1977) J. Biochem 81, 215-232). In the present study, it was experimentally shown that chicken serum albumin does not have any of the actions of beta-actinin: inhibition of reassociation of F-actin fragments, retardation of depolymerization of F-actin, instability of F-actin, acceleration of polymerization of G-actin, and formation of Mg polymer. The role of muscle beta-actinin, a heterodimer of 37,000 and 34,000 daltons, in the regulation of myofibrillar structure is summarized.
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