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  • Title: Pesticide induced changes in the mouse hepatic microsomal cytochrome P-450-dependent monooxygenase system and other enzymes.
    Author: Robacker KM, Kulkarni AP, Hodgson E.
    Journal: J Environ Sci Health B; 1981; 16(5 Pt B):529-45. PubMed ID: 7299069.
    Abstract:
    Livers of mice previously treated with potential inducers were tested for effects on the microsomal cytochrome P-450-dependent monooxygenase system (including its constituent electron transport enzymes) and other enzymes. Microsomes were also examined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Pesticides, including chlorinated hydrocarbons, organophosphates, a carbamate, and an insecticide synergistic were tested for induction along with the well known inducers, phenobarbital and 3-methylcholanthrene. The results indicate that the pesticide inducers tested are of the phenobarbital type.
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