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  • Title: In-vitro uptake and metabolism of [3H] corticosterone by mammary glands from pregnant, lactating, and post-lactational rats and by parametrial adipose tissue from lactating rats.
    Author: Pearlman WH, Peng LH, Pearlman MR.
    Journal: J Endocrinol; 1981 Oct; 91(1):81-8. PubMed ID: 7299321.
    Abstract:
    The study was designed to determine the influence of the physiological state on the in-vitro uptake and metabolism of glucocorticoid hormone by the mammary gland. [3H] Corticosterone was accordingly incubated with minced mammary glands from pregnant, lactating and post-lactational rats. The total uptake of [3H] corticosteroid was obtained from the concentration of radioactivity by the tissue and the specific activity of the steroid substrate. The extent of 21-acylation was determined as the percentage of the radioactivity in the chromatographed tissue extracts attributable to 21-acyl-[3H] corticosterone. The results indicated that the uptake of [3H] corticosteroid increased with advancing pregnancy, attained a high plateau level during lactation, and steadily declined during the post-lactational period. The extent of 21-acylation of [3H] corticosterone varied from 10 to 40%, fluctuating widely in all physiological states, particularly during the post-lactational period. It was inferred that the stromal elements, presumably the adipocytes, of the mammary gland can also acylate the corticosteroid hormone, a view which gained experimental support from similar studies with minced parametrial adipose tissue from lactating rats.
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