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  • Title: Application of one-phase end-point change system in two-phase titration to amine drug analysis.
    Author: Tsubouchi M, Mitsushio H, Yamasaki N, Matsuoka K.
    Journal: J Pharm Sci; 1981 Nov; 70(11):1286-8. PubMed ID: 7299680.
    Abstract:
    A titration method was developed for the determination of diphenhydramine, quinine, neostigmine, sparteine, strychnine, homatropine, atropine, physostigmine, and procaine in aqueous solution. Tetraphenylborate was used as a titrant with tetrabromophenolphthalein ethyl ester as an indicator in the presence of organic solvent. End-point detection was based on the color change of the indicator in the organic phase without movement of the indicator from one phase to the other.
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